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Publications of Eduardo D. Sontag jointly with Q. Tyles
Conference articles
  1. Q. Tyles, T. Kang, E.D. Sontag, and L. Bleris. Exploring the impact of resource limitations on gene network reconstruction. In Proc. IEEE Conf. Decision and Control, Dec. 2016, pages 3350-3355, 2016. [PDF] Keyword(s): Biological systems, Genetic regulatory systems, Systems biology.
    Abstract:
    Applying Modular Response Analysis to a synthetic gene circuit, which was introduced in a recent paper by the authors, leads to the inference of a nontrivial "ghost" regulation edge which was not explicitly engineered into the network and which is, in fact, not immediately apparent from experimental measurements. One may thus hypothesize that this ghost regulatory effect is due to competition for resources. A mathematical model is proposed, and analyzed in closed form, that lends validation to this hypothesis.



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Last modified: Thu Nov 23 10:40:56 2017
Author: sontag.


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