Publications of Eduardo D. Sontag jointly with M. Meads
Articles in journal or book chapters
  1. A. Silva, M. Silva, P. Sudalagunta, A. Distler, T. Jacobson, A. Collins, T. Nguyen, J. Song, D.T. Chen, Lu Chen, . Cubitt, R. Baz, L. Perez, D. Rebatchouk, W. Dalton, J. Greene, R. Gatenby, R. Gillies, E.D. Sontag, M. Meads, and K. Shain. An ex vivo platform for the prediction of clinical response in multiple myeloma. Cancer Research, pp 10.1158/0008-5472.CAN-17-0502, 2017. Keyword(s): cancer, multiple myeloma, personalized therapy.
    This paper describes a novel approach for characterization of chemosensitivity and prediction of clinical response in multiple myeloma. It relies upon a patient-specific computational model of clinical response, parameterized by a high-throughput ex vivo assay that quantifies sensitivity of primary MM cells to 31 agents or combinations, in a reconstruction of the tumor microenvironment. The mathematical model, which inherently accounts for intra-tumoral heterogeneity of drug sensitivity, combined with drug- and regimen-specific pharmacokinetics, produces patient-specific predictions of clinical response 5 days post-biopsy.



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Last modified: Thu Nov 23 10:40:56 2017
Author: sontag.

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