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Publications of Eduardo D. Sontag jointly with . Cubitt
Articles in journal or book chapters
  1. A. Silva, M. Silva, P. Sudalagunta, A. Distler, T. Jacobson, A. Collins, T. Nguyen, J. Song, D.T. Chen, Lu Chen, . Cubitt, R. Baz, L. Perez, D. Rebatchouk, W. Dalton, J. Greene, R. Gatenby, R. Gillies, E.D. Sontag, M. Meads, and K. Shain. An ex vivo platform for the prediction of clinical response in multiple myeloma. Cancer Research, pp 10.1158/0008-5472.CAN-17-0502, 2017. Keyword(s): cancer, multiple myeloma, personalized therapy.
    Abstract:
    This paper describes a novel approach for characterization of chemosensitivity and prediction of clinical response in multiple myeloma. It relies upon a patient-specific computational model of clinical response, parameterized by a high-throughput ex vivo assay that quantifies sensitivity of primary MM cells to 31 agents or combinations, in a reconstruction of the tumor microenvironment. The mathematical model, which inherently accounts for intra-tumoral heterogeneity of drug sensitivity, combined with drug- and regimen-specific pharmacokinetics, produces patient-specific predictions of clinical response 5 days post-biopsy.



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Last modified: Thu Nov 23 10:40:56 2017
Author: sontag.


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